Cargando…
Dysregulated ECM remodeling proteins lead to aberrant osteogenesis of Costello syndrome iPSCs
Costello syndrome (CS) is an autosomal dominant disorder caused by mutations in HRAS. Although CS patients have skeletal abnormalities, the role of mutated HRAS in bone development remains unclear. Here, we use CS induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to invest...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365028/ https://www.ncbi.nlm.nih.gov/pubmed/34242618 http://dx.doi.org/10.1016/j.stemcr.2021.06.007 |