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The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells

Histone variants contribute to the complexity of the chromatin landscape and play an integral role in defining DNA domains and regulating gene expression. The histone H3 variant H3.3 is incorporated into genic elements independent of DNA replication by its chaperone HIRA. Here we demonstrate that Hi...

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Detalles Bibliográficos
Autores principales: Murdaugh, Rebecca L., Hoegenauer, Kevin A., Kitano, Ayumi, Holt, Matthew V., Hill, Matthew C., Shi, Xiangguo, Tiessen, Jonathan F., Chapple, Richard, Hu, Tianyuan, Tseng, Yu-Jung, Lin, Angelique, Martin, James F., Young, Nicolas L., Nakada, Daisuke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365107/
https://www.ncbi.nlm.nih.gov/pubmed/34242617
http://dx.doi.org/10.1016/j.stemcr.2021.06.009