Cargando…

Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology

Microglia play critical roles in brain development, homeostasis, and disease. Microglia in animal models cannot accurately model human microglia due to notable transcriptomic and functional differences between human and other animal microglia. Incorporating human pluripotent stem cell (hPSC)-derived...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Ranjie, Boreland, Andrew J., Li, Xiaoxi, Erickson, Caroline, Jin, Mengmeng, Atkins, Colm, Pang, Zhiping P., Daniels, Brian P., Jiang, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365109/ https://www.ncbi.nlm.nih.gov/pubmed/34297942 http://dx.doi.org/10.1016/j.stemcr.2021.06.011

Ejemplares similares

A Cerebral Organoid Connectivity Apparatus to Model Neuronal Tract Circuitry
por: Robles, Denise A., et al.
Publicado: (2021)

Human iPSC-derived mature microglia retain their identity and functionally integrate in the chimeric mouse brain
por: Xu, Ranjie, et al.
Publicado: (2020)

Dysregulated neuroimmune interactions and sustained type I interferon signaling after human immunodeficiency virus type 1 infection of human iPSC derived microglia and cerebral organoids
por: Boreland, Andrew J., et al.
Publicado: (2023)

Microglia innately develop within cerebral organoids
por: Ormel, Paul R., et al.
Publicado: (2018)

Pluripotent Stem Cell-Derived Cerebral Organoids Reveal Human Oligodendrogenesis with Dorsal and Ventral Origins
por: Kim, Hyosung, et al.
Publicado: (2019)

Microglia-containing human brain organoids for the study of brain development and pathology
por: Zhang, Wendiao, et al.
Publicado: (2022)

Microglia-containing cerebral organoids derived from induced pluripotent stem cells for the study of neurological diseases
por: Hong, Yiling, et al.
Publicado: (2023)

Novel Scalable and Simplified System to Generate Microglia-Containing Cerebral Organoids From Human Induced Pluripotent Stem Cells
por: Bodnar, Brittany, et al.
Publicado: (2021)

Microglia-like Cells Promote Neuronal Functions in Cerebral Organoids
por: Fagerlund, Ilkka, et al.
Publicado: (2021)

Characterization of HIV-1 Infection in Microglia-Containing Human Cerebral Organoids
por: Gumbs, Stephanie B. H., et al.
Publicado: (2022)

Incorporating microglia‐like cells in human induced pluripotent stem cell‐derived retinal organoids
por: Chichagova, Valeria, et al.
Publicado: (2023)

Cerebral organoids model human brain development and microcephaly
por: Lancaster, Madeline A., et al.
Publicado: (2013)

Modeling human brain development with cerebral organoids
por: Muzio, Luca, et al.
Publicado: (2013)

Microglial over-pruning of synapses during development in autism-associated SCN2A-deficient mice and human cerebral organoids
por: Yang, Yang, et al.
Publicado: (2023)

Development and Characterization of Human Cerebral Organoids: An Optimized Protocol
por: Yakoub, Abraam M., et al.
Publicado: (2018)

Modeling Brain Somatic Mosaicism With Cerebral Organoids, Including a Note on Mutant Microglia
por: Verheijen, Bert M.
Publicado: (2019)

Robust production of uniform human cerebral organoids from pluripotent stem cells
por: Sivitilli, Adam A, et al.
Publicado: (2020)

Modeling human development and disease in pluripotent stem cell-derived gastric organoids
por: McCracken, Kyle W., et al.
Publicado: (2014)

Pluripotent stem cell‐derived retinal organoids for disease modeling and development of therapies
por: Kruczek, Kamil, et al.
Publicado: (2020)

Insights to Heart Development and Cardiac Disease Models Using Pluripotent Stem Cell Derived 3D Organoids
por: Pang, Jeremy Kah Sheng, et al.
Publicado: (2021)

Retraction: Modeling Brain Somatic Mosaicism With Cerebral Organoids, Including a Note on Mutant Microglia
Publicado: (2020)

A Simple Method for Generating Cerebral Organoids from Human Pluripotent Stem Cells
por: Hong, Yean Ju, et al.
Publicado: (2022)

Induced pluripotent stem cells and cerebral organoids from the critically endangered Sumatran rhinoceros
por: Zywitza, Vera, et al.
Publicado: (2022)

A facile method to generate cerebral organoids from human pluripotent stem cells
por: Simorgh, Susan, et al.
Publicado: (2023)

Modeling human liver organ development and diseases with pluripotent stem cell-derived organoids
por: Ouchi, Rie, et al.
Publicado: (2023)

Cardiac Organoids and Gastruloids to Study Physio-Pathological Heart Development
por: Jaconi, Marisa E., et al.
Publicado: (2021)

Patient-Derived Induced Pluripotent Stem Cells (iPSCs) and Cerebral Organoids for Drug Screening and Development in Autism Spectrum Disorder: Opportunities and Challenges
por: Villa, Chiara, et al.
Publicado: (2021)

Generation of human induced pluripotent stem cell-derived cerebral organoids for cellular and molecular characterization
por: Anastasaki, Corina, et al.
Publicado: (2022)

Human‐induced pluripotent stem cell‐derived cerebral organoid of leukoencephalopathy with vanishing white matter
por: Deng, Jiong, et al.
Publicado: (2023)

Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development
por: Fair, Summer R., et al.
Publicado: (2020)

Glioblastoma and cerebral organoids: development and analysis of an in vitro model for glioblastoma migration
por: Fedorova, Veronika, et al.
Publicado: (2023)

Nephron organoids derived from human pluripotent stem cells model kidney development and injury
por: Morizane, Ryuji, et al.
Publicado: (2015)

Modeling endodermal organ development and diseases using human pluripotent stem cell-derived organoids
por: Pan, Fong Cheng, et al.
Publicado: (2020)

Insights Into Human Development and Disease From Human Pluripotent Stem Cell Derived Intestinal Organoids
por: Daoud, Abdelkader, et al.
Publicado: (2019)

Bulk RNA sequencing analysis of developing human induced pluripotent cell-derived retinal organoids
por: Agarwal, Devansh, et al.
Publicado: (2022)

Human striatal organoids derived from pluripotent stem cells recapitulate striatal development and compartments
por: Chen, Xinyu, et al.
Publicado: (2022)

Design Principles for Pluripotent Stem Cell-Derived Organoid Engineering
por: Silva, Teresa P., et al.
Publicado: (2019)

Cerebral organoids derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation
por: Allende, Maria L., et al.
Publicado: (2018)

Generation of Standardized and Reproducible Forebrain-type Cerebral Organoids from Human Induced Pluripotent Stem Cells
por: Krefft, Olivia, et al.
Publicado: (2018)

A simple method to improve the quality and yield of human pluripotent stem cell-derived cerebral organoids
por: Choe, Mu Seog, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_cdhlpl3on9196v17ol6kgltmle