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Developing human pluripotent stem cell-based cerebral organoids with a controllable microglia ratio for modeling brain development and pathology
Microglia play critical roles in brain development, homeostasis, and disease. Microglia in animal models cannot accurately model human microglia due to notable transcriptomic and functional differences between human and other animal microglia. Incorporating human pluripotent stem cell (hPSC)-derived...
Autores principales: | Xu, Ranjie, Boreland, Andrew J., Li, Xiaoxi, Erickson, Caroline, Jin, Mengmeng, Atkins, Colm, Pang, Zhiping P., Daniels, Brian P., Jiang, Peng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365109/ https://www.ncbi.nlm.nih.gov/pubmed/34297942 http://dx.doi.org/10.1016/j.stemcr.2021.06.011 |
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