Increased levels of mitochondrial import factor Mia40 prevent the aggregation of polyQ proteins in the cytosol

The formation of protein aggregates is a hallmark of neurodegenerative diseases. Observations on patient samples and model systems demonstrated links between aggregate formation and declining mitochondrial functionality, but causalities remain unclear. We used Saccharomyces cerevisiae to analyze how...

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Detalles Bibliográficos
Autores principales: Schlagowski, Anna M, Knöringer, Katharina, Morlot, Sandrine, Sánchez Vicente, Ana, Flohr, Tamara, Krämer, Lena, Boos, Felix, Khalid, Nabeel, Ahmed, Sheraz, Schramm, Jana, Murschall, Lena M, Haberkant, Per, Stein, Frank, Riemer, Jan, Westermann, Benedikt, Braun, Ralf J, Winklhofer, Konstanze F, Charvin, Gilles, Herrmann, Johannes M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365258/
https://www.ncbi.nlm.nih.gov/pubmed/34191328
http://dx.doi.org/10.15252/embj.2021107913

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365258/
https://www.ncbi.nlm.nih.gov/pubmed/34191328
http://dx.doi.org/10.15252/embj.2021107913

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