Cargando…

EZH2/EHMT2 Histone Methyltransferases Inhibit the Transcription of DLX5 and Promote the Transformation of Myelodysplastic Syndrome to Acute Myeloid Leukemia

Myelodysplastic syndrome (MDS) is characterized by clonal hematopoiesis and impaired differentiation, and may develop to acute myeloid leukemia (AML). We explored the mechanism of histone methyltransferase EZH2/EHMT2 during the transformation of MDS into AML. Expression of EZH2/EHMT2 in patients and...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zheng, Zhuanzhen, Li, Ling, Li, Guoxia, Zhang, Yaofang, Dong, Chunxia, Ren, Fanggang, Chen, Wenliang, Ma, Yanping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365305/ https://www.ncbi.nlm.nih.gov/pubmed/34409024 http://dx.doi.org/10.3389/fcell.2021.619795

Ejemplares similares

MEK/ERK and PI3K/AKT pathway inhibitors affect the transformation of myelodysplastic syndrome into acute myeloid leukemia via H3K27me3 methylases and de-methylases
por: Zheng, Zhuanzhen, et al.
Publicado: (2023)

Dual EZH2 and EHMT2 histone methyltransferase inhibition increases biological efficacy in breast cancer cells
por: Curry, Edward, et al.
Publicado: (2015)

De novo methylation of histone H3K23 by the methyltransferases EHMT1/GLP and EHMT2/G9a
por: Vinson, David A., et al.
Publicado: (2022)

Histone Methyltransferases G9a/Ehmt2 and GLP/Ehmt1 Are Associated with Cell Viability and Poorer Prognosis in Neuroblastoma and Ewing Sarcoma
por: Souza, Barbara Kunzler, et al.
Publicado: (2023)

Dual inhibition of EZH2 and G9A/GLP histone methyltransferases by HKMTI-1-005 promotes differentiation of acute myeloid leukemia cells
por: Sbirkov, Y., et al.
Publicado: (2023)

Histone methyltransferases EHMT1 and EHMT2 (GLP/G9A) maintain PARP inhibitor resistance in high-grade serous ovarian carcinoma
por: Watson, Zachary L., et al.
Publicado: (2019)

Identification by high-throughput imaging of the histone methyltransferase EHMT2 as an epigenetic regulator of VEGFA alternative splicing
por: Salton, Maayan, et al.
Publicado: (2014)

The histone methyltransferase Ezh2 restrains macrophage inflammatory responses
por: Kitchen, Gareth B., et al.
Publicado: (2021)

TNFα Effects on Adipocytes Are Influenced by the Presence of Lysine Methyltransferases, G9a (EHMT2) and GLP (EHMT1)
por: Able, Ashley A., et al.
Publicado: (2023)

Functional convergence of histone methyltransferases EHMT1 and KMT2C involved in intellectual disability and autism spectrum disorder
por: Koemans, Tom S., et al.
Publicado: (2017)

Euchromatin histone methyltransferase II (EHMT2) regulates the expression of ras-related GTP binding C (RRAGC) protein
por: Hwang, Supyong, et al.
Publicado: (2020)

The structure of the cysteine-rich region from human histone-lysine N-methyltransferase EHMT2 (G9a)
por: Kerchner, Keshia M., et al.
Publicado: (2021)

Multiple regulatory aspects of histone methyltransferase EZH2 in Pb-induced neurotoxicity
por: Xue, Wei-Zhen, et al.
Publicado: (2017)

Histone Methyltransferase EZH2: A Potential Therapeutic Target for Kidney Diseases
por: Li, Tingting, et al.
Publicado: (2021)

Epigenetic Silencing of CHOP Expression by the Histone Methyltransferase EHMT1 Regulates Apoptosis in Colorectal Cancer Cells
por: Kim, Kwangho, et al.
Publicado: (2022)

Targeting EZH2 histone methyltransferase activity alleviates experimental intestinal inflammation
por: Zhou, Jie, et al.
Publicado: (2019)

Histone‐lysine N‐methyltransferase EHMT2 (G9a) inhibition mitigates tumorigenicity in Myc‐driven liver cancer
por: Thng, Dexter Kai Hao, et al.
Publicado: (2023)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites
por: Watanabe, Sugiko, et al.
Publicado: (2018)

Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy
por: Kang, Zhihua, et al.
Publicado: (2023)

Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer
por: Taniguchi, H, et al.
Publicado: (2012)

Symphony of epigenetic and metabolic regulation—interaction between the histone methyltransferase EZH2 and metabolism of tumor
por: Zhang, Tengrui, et al.
Publicado: (2020)

Inhibition of histone methyltransferase EZH2 ameliorates early acute renal allograft rejection in rats
por: Li, Long, et al.
Publicado: (2016)

CARM1-expressing ovarian cancer depends on the histone methyltransferase EZH2 activity
por: Karakashev, Sergey, et al.
Publicado: (2018)

Ezh2 promotes clock function and hematopoiesis independent of histone methyltransferase activity in zebrafish
por: Zhong, Yingbin, et al.
Publicado: (2018)

The Role of the Histone Methyltransferase EZH2 in Liver Inflammation and Fibrosis in STAM NASH Mice
por: Lee, Seul, et al.
Publicado: (2020)

Loss-of-function mutations in the histone methyltransferase EZH2 promote chemotherapy resistance in AML
por: Kempf, Julia M., et al.
Publicado: (2021)

m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2
por: Chen, Junchen, et al.
Publicado: (2019)

The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration
por: Zhang, Regan-Heng, et al.
Publicado: (2016)

Analogues of the natural product Sinefungin as potent inhibitors of EHMT1 and EHMT2
por: Devkota, Kanchan, et al.
Publicado: (2013)

Histone methyltransferase KMT2D contributes to the protection of myocardial ischemic injury
por: Liu, Shu-Bao, et al.
Publicado: (2022)

The phosphatase interactor NIPP1 regulates the occupancy of the histone methyltransferase EZH2 at Polycomb targets
por: Van Dessel, Nele, et al.
Publicado: (2010)

The histone methyltransferase EZH2 as a druggable target in SHH medulloblastoma cancer stem cells
por: Miele, Evelina, et al.
Publicado: (2017)

Inhibition of the Histone Methyltransferase EZH2 Enhances Protumor Monocyte Recruitment in Human Mesothelioma Spheroids
por: Mola, Silvia, et al.
Publicado: (2021)

Poly(ADP-ribose) Polymerase 1, PARP1, modifies EZH2 and inhibits EZH2 histone methyltransferase activity after DNA damage
por: Caruso, Lisa B., et al.
Publicado: (2018)

Histone demethylase KDM2B upregulates histone methyltransferase EZH2 expression and contributes to the progression of ovarian cancer in vitro and in vivo
por: Kuang, Yan, et al.
Publicado: (2017)

The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection
por: Chen, Xiangyu, et al.
Publicado: (2019)

New epigenetic pathway for stemness maintenance mediated by the histone methyltransferase Ezh1
por: Hidalgo, Isabel, et al.
Publicado: (2013)

Histone Lysine Methyltransferase SETD2 Regulates Coronary Vascular Development in Embryonic Mouse Hearts
por: Chen, Fengling, et al.
Publicado: (2021)

Weaver Syndrome‐Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro
por: Cohen, Ana S.A., et al.
Publicado: (2016)

The histone methyltransferase EZH2 as a novel prosurvival factor in clinically aggressive chronic lymphocytic leukemia
por: Papakonstantinou, Nikos, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_kunbhdfgp2kq7t7g2jbcl7h2gn