Aptamer-mediated transcriptional gene silencing of Foxp3 inhibits regulatory T cells and potentiates antitumor response

The inhibition of immunosuppressive mechanisms may switch the balance between tolerance and surveillance, leading to an increase in antitumor activity. Regulatory T cells play an important role in the control of immunosuppression, exhibiting the unique property of inhibiting T cell proliferation. Th...

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Detalles Bibliográficos
Autores principales: Manrique-Rincón, Andrea J., Ruas, Luciana P., Fogagnolo, Carolinne T., Brenneman, Randall J., Berezhnoy, Alexey, Castelucci, Bianca, Consonni, Sílvio R., Gilboa, Eli, Bajgelman, Marcio C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365334/
https://www.ncbi.nlm.nih.gov/pubmed/34457999
http://dx.doi.org/10.1016/j.omtn.2021.05.005

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365334/
https://www.ncbi.nlm.nih.gov/pubmed/34457999
http://dx.doi.org/10.1016/j.omtn.2021.05.005

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