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An epigenetic and transcriptomic signature of immune tolerance in human monocytes through multi-omics integration
BACKGROUND: The plasticity of monocytes enables them to exert multiple roles during an immune response, including promoting immune tolerance. How monocytes alter their functions to convey immune tolerance in the context of lower respiratory tract infections in humans is not well understood. Here, we...
Autores principales: | Brands, Xanthe, Haak, Bastiaan W., Klarenbeek, Augustijn M., Butler, Joe, Uhel, Fabrice, Qin, Wanhai, Otto, Natasja A., Jakobs, Marja E., Faber, Daniël R., Lutter, René, Wiersinga, W. Joost, van der Poll, Tom, Scicluna, Brendon P. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365568/ https://www.ncbi.nlm.nih.gov/pubmed/34399830 http://dx.doi.org/10.1186/s13073-021-00948-1 |
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