Structural Insights into Notum Covalent Inhibition

[Image: see text] The carboxylesterase Notum hydrolyzes a palmitoleate moiety from Wingless/Integrated(Wnt) ligands and deactivates Wnt signaling. Notum inhibitors can restore Wnt signaling which may be of therapeutic benefit for pathologies such as osteoporosis and Alzheimer’s disease. We report th...

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Detalles Bibliográficos
Autores principales: Zhao, Yuguang, Svensson, Fredrik, Steadman, David, Frew, Sarah, Monaghan, Amy, Bictash, Magda, Moreira, Tiago, Chalk, Rod, Lu, Weixian, Fish, Paul V., Jones, E. Yvonne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365597/
https://www.ncbi.nlm.nih.gov/pubmed/34292747
http://dx.doi.org/10.1021/acs.jmedchem.1c00701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365597/
https://www.ncbi.nlm.nih.gov/pubmed/34292747
http://dx.doi.org/10.1021/acs.jmedchem.1c00701

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