Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction

[Image: see text] We describe a new class of potent PD-L1/PD-1 inhibitors based on a terphenyl scaffold that is derived from the rigidified biphenyl-inspired structure. Using in silico docking, we designed and then experimentally demonstrated the effectiveness of the terphenyl-based scaffolds in inh...

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Detalles Bibliográficos
Autores principales: Muszak, Damian, Surmiak, Ewa, Plewka, Jacek, Magiera-Mularz, Katarzyna, Kocik-Krol, Justyna, Musielak, Bogdan, Sala, Dominik, Kitel, Radoslaw, Stec, Malgorzata, Weglarczyk, Kazimierz, Siedlar, Maciej, Dömling, Alexander, Skalniak, Lukasz, Holak, Tad A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365601/
https://www.ncbi.nlm.nih.gov/pubmed/34313116
http://dx.doi.org/10.1021/acs.jmedchem.1c00957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365601/
https://www.ncbi.nlm.nih.gov/pubmed/34313116
http://dx.doi.org/10.1021/acs.jmedchem.1c00957

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