VEGFR-2 redirected CAR-T cells are functionally impaired by soluble VEGF-A competition for receptor binding

BACKGROUND: The adoptive transfer of chimeric antigen receptor (CAR)-T cells has emerged as a potent immunotherapy against some hematological malignancies but not yet for epithelial-derived solid tumors. One critical issue is the paucity of broadly expressed solid tumor antigens (TAs), and another i...

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Detalles Bibliográficos
Autores principales: Lanitis, Evripidis, Kosti, Paris, Ronet, Catherine, Cribioli, Elisabetta, Rota, Giorgia, Spill, Aodrenn, Reichenbach, Patrick, Zoete, Vincent, Dangaj Laniti, Denarda, Coukos, George, Irving, Melita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2021
Materias:
Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365827/
https://www.ncbi.nlm.nih.gov/pubmed/34389616
http://dx.doi.org/10.1136/jitc-2020-002151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365827/
https://www.ncbi.nlm.nih.gov/pubmed/34389616
http://dx.doi.org/10.1136/jitc-2020-002151

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