Cargando…

Urinary metabolomic changes and microbiotic alterations in presenilin1/2 conditional double knockout mice

BACKGROUND: Given the clinical low efficient treatment based on mono-brain-target design in Alzheimer’s disease (AD) and an increasing emphasis on microbiome-gut-brain axis which was considered as a crucial pathway to affect the progress of AD along with metabolic changes, integrative metabolomic si...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Jie, Zhou, Nian, Wu, Yongkang, Lu, Mengna, Wang, Qixue, Xia, Chenyi, Zhou, Mingmei, Xu, Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365912/ https://www.ncbi.nlm.nih.gov/pubmed/34399766 http://dx.doi.org/10.1186/s12967-021-03032-9

Ejemplares similares

Effects of electroacupuncture on urinary metabolome and microbiota in presenilin1/2 conditional double knockout mice
por: Gao, Jie, et al.
Publicado: (2023)

Ibuprofen Rescues Abnormalities in Periodontal Tissues in Conditional Presenilin 1 and Presenilin 2 Double Knockout Mice
por: Su, Jiansheng, et al.
Publicado: (2013)

Spatiotemporal patterns of gliosis and neuroinflammation in presenilin 1/2 conditional double knockout mice
por: Peng, Wenjun, et al.
Publicado: (2022)

Autoimmunity and COVID-19 – The microbiotal connection
por: Katz-Agranov, Nurit, et al.
Publicado: (2021)

Brain Mitochondrial Dysfunction: A Possible Mechanism Links Early Life Anxiety to Alzheimer’s Disease in Later Life
por: Wang, Qixue, et al.
Publicado: (2022)

Guizhi Fuling capsule relieves memory deficits by inhibition of microglial neuroinflammation through blocking JAK2/STAT3 pathway in presenilin1/2 conditional double knockout mice
por: Yang, Guang, et al.
Publicado: (2023)

Barrier function and microbiotic dysbiosis in atopic dermatitis
por: Seite, Sophie, et al.
Publicado: (2015)

Integrated network pharmacology and hepatic metabolomics to reveal the mechanism of Acanthopanax senticosus against major depressive disorder
por: Gu, Xinyi, et al.
Publicado: (2022)

Electroacupuncture Ameliorates Neuroinflammation-Mediated Cognitive Deficits through Inhibition of NLRP3 in Presenilin1/2 Conditional Double Knockout Mice
por: Li, Kun, et al.
Publicado: (2021)

Obesity and Its Multiple Clinical Implications between Inflammatory States and Gut Microbiotic Alterations
por: Milano, Walter, et al.
Publicado: (2022)

The Role of Gut Microbiota-Bile Acids Axis in the Progression of Non-alcoholic Fatty Liver Disease
por: Ni, Yiming, et al.
Publicado: (2022)

Gut Microbiotic Features Aiding the Diagnosis of Acute Ischemic Stroke
por: Xiang, Lei, et al.
Publicado: (2020)

Investigation of Gynura segetum root extract (GSrE) induced hepatotoxicity based on metabolomic signatures and microbial community profiling in rats
por: Gu, Xinyi, et al.
Publicado: (2022)

Enterogenous Microbiotic Markers in the Differential Diagnosis of Crohn’s Disease and Intestinal Tuberculosis
por: Jiang, Mingshan, et al.
Publicado: (2022)

Contribution of Symptomatic, Herbal Treatment Options to Antibiotic Stewardship and Microbiotic Health
por: Nausch, Bernhard, et al.
Publicado: (2022)

Analysis of gut microbiotal diversity in healthy young adults in Sunan County, Gansu Province, China
por: Ma, Yanqing, et al.
Publicado: (2023)

In Vitro Microbiotic Fermentation Causes an Extensive Metabolite Turnover of Rye Bran Phytochemicals
por: Hanhineva, Kati, et al.
Publicado: (2012)

The presenilins
por: Tandon, Anurag, et al.
Publicado: (2002)

The Microbiotic Highway to Health—New Perspective on Food Structure, Gut Microbiota, and Host Inflammation
por: Hansen, Nina Wærling, et al.
Publicado: (2018)

Antibacterial and Antiviral Properties of Tetrahydrocurcumin-Based Formulations: An Overview of Their Metabolism in Different Microbiotic Compartments
por: Atanasova-Panchevska, Natalija, et al.
Publicado: (2022)

The Impact of Instant Coffee and Decaffeinated Coffee on the Gut Microbiota and Depression-Like Behaviors of Sleep-Deprived Rats
por: Gu, Xinyi, et al.
Publicado: (2022)

Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer’s Disease Pathogenesis
por: Barazzuol, Lucia, et al.
Publicado: (2023)

Behçet's Disease Under Microbiotic Surveillance? A Combined Analysis of Two Cohorts of Behçet's Disease Patients
por: van der Houwen, Tim B., et al.
Publicado: (2020)

Immunogenetic, Molecular and Microbiotic Determinants of Eosinophilic Esophagitis and Clinical Practice—A New Perspective of an Old Disease
por: Kanikowska, Alina, et al.
Publicado: (2021)

Correlation between intestinal microbiotal imbalance and 5‐HT metabolism, immune inflammation in chronic unpredictable mild stress male rats
por: Li, Huawei, et al.
Publicado: (2022)

Adult hippocampal neurogenesis occurs in the absence of Presenilin 1 and Presenilin 2
por: Dhaliwal, Jagroop, et al.
Publicado: (2018)

Structure and dynamics of γ-secretase with presenilin 2 compared to presenilin 1
por: Dehury, Budheswar, et al.
Publicado: (2019)

Characterization of Age-Dependent and Progressive Cortical Neuronal Degeneration in Presenilin Conditional Mutant Mice
por: Wines-Samuelson, Mary, et al.
Publicado: (2010)

Phages versus Antibiotics To Treat Infected Diabetic Wounds in a Mouse Model: a Microbiological and Microbiotic Evaluation
por: Huon, Jean-François, et al.
Publicado: (2020)

The Changes in Microbiotic Composition of Different Intestinal Tracts and the Effects of Supplemented Lactobacillus During the Formation of Goose Fatty Liver
por: Wen, Kang, et al.
Publicado: (2022)

Identification of Ubiquilin, a Novel Presenilin Interactor That Increases Presenilin Protein Accumulation
por: Mah, Alex L., et al.
Publicado: (2000)

Altered Urinary Metabolomics in Hereditary Angioedema
por: Wang, Xue, et al.
Publicado: (2022)

Specificity of presenilin‐1‐ and presenilin‐2‐dependent γ‐secretases towards substrate processing
por: Stanga, Serena, et al.
Publicado: (2017)

Serum metabolomics strategy for investigating the hepatotoxicity induced by different exposure times and doses of Gynura segetum (Lour.) Merr. in rats based on GC-MS
por: Li, Ying, et al.
Publicado: (2023)

Pathological and physiological functions of presenilins
por: Vetrivel, Kulandaivelu S, et al.
Publicado: (2006)

Presenilin/γ-Secretase and Inflammation
por: Saura, Carlos A.
Publicado: (2010)

Identification of potential targets of cinnamon for treatment against Alzheimer’s disease-related GABAergic synaptic dysfunction using network pharmacology
por: Qian, Dongdong, et al.
Publicado: (2022)

Parkin acts as a transcription factor modulating presenilin-1 and presenilin-2 promoter transactivations
por: Duplan, Eric, et al.
Publicado: (2013)

Low Oral Bioavailability and Partial Gut Microbiotic and Phase II Metabolism of Brussels/Witloof Chicory Sesquiterpene Lactones in Healthy Humans
por: Weng, Hui, et al.
Publicado: (2020)

Modeling Presenilin-Dependent Familial Alzheimer's Disease: Emphasis on Presenilin Substrate-Mediated Signaling and Synaptic Function
por: Parent, Angèle T., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_balab5918i5lp7jd1m46qsr06h