Efficient conversion of phytosterols into 4-androstene-3,17-dione and its C1,2-dehydrogenized and 9α-hydroxylated derivatives by engineered Mycobacteria

4-Androstene-3,17-dione (4-AD), 1,4-androstadiene-3,17-dione (ADD) and 9α-hydroxyl-4-androstene-3,17-dione (9OH-AD), which are important starting compounds for the synthesis of steroidal medicines, can be biosynthetically transformed from phytosterols by Mycobacterium strains. Genomic and metabolic...

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Detalles Bibliográficos
Autores principales: Li, Xin, Chen, Tian, Peng, Fei, Song, Shikui, Yu, Jingpeng, Sidoine, Douanla Njimeli, Cheng, Xiyao, Huang, Yongqi, He, Yijun, Su, Zhengding
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365914/
https://www.ncbi.nlm.nih.gov/pubmed/34399754
http://dx.doi.org/10.1186/s12934-021-01653-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365914/
https://www.ncbi.nlm.nih.gov/pubmed/34399754
http://dx.doi.org/10.1186/s12934-021-01653-9

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