Cargando…

Efficient conversion of phytosterols into 4-androstene-3,17-dione and its C1,2-dehydrogenized and 9α-hydroxylated derivatives by engineered Mycobacteria

4-Androstene-3,17-dione (4-AD), 1,4-androstadiene-3,17-dione (ADD) and 9α-hydroxyl-4-androstene-3,17-dione (9OH-AD), which are important starting compounds for the synthesis of steroidal medicines, can be biosynthetically transformed from phytosterols by Mycobacterium strains. Genomic and metabolic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Xin, Chen, Tian, Peng, Fei, Song, Shikui, Yu, Jingpeng, Sidoine, Douanla Njimeli, Cheng, Xiyao, Huang, Yongqi, He, Yijun, Su, Zhengding
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8365914/ https://www.ncbi.nlm.nih.gov/pubmed/34399754 http://dx.doi.org/10.1186/s12934-021-01653-9

Ejemplares similares

Driving the conversion of phytosterol to 9α-hydroxy-4-androstene-3,17-dione in Mycolicibacterium neoaurum by engineering the supply and regeneration of flavin adenine dinucleotide
por: Song, Lu, et al.
Publicado: (2023)

Loop pathways are responsible for tuning the accumulation of C19- and C22-sterol intermediates in the mycobacterial phytosterol degradation pathway
por: Song, Shikui, et al.
Publicado: (2023)

Whole-genome and enzymatic analyses of an androstenedione-producing Mycobacterium strain with residual phytosterol-degrading pathways
por: Wang, Hongwei, et al.
Publicado: (2020)

A Novel 3-Phytosterone-9α-Hydroxylase Oxygenation Component and Its Application in Bioconversion of 4-Androstene-3,17-Dione to 9α-Hydroxy-4-Androstene-3,17-Dione Coupling with A NADH Regeneration Formate Dehydrogenase
por: Zhang, Xian, et al.
Publicado: (2019)

Improving the production of 9α-hydroxy-4-androstene-3,17-dione from phytosterols by 3-ketosteroid-Δ(1)-dehydrogenase deletions and multiple genetic modifications in Mycobacterium fortuitum
por: Liu, Xiangcen, et al.
Publicado: (2023)

One-pot biosynthesis of 7β-hydroxyandrost-4-ene-3,17-dione from phytosterols by cofactor regeneration system in engineered mycolicibacterium neoaurum
por: Zhao, Yun-Qiu, et al.
Publicado: (2022)

Redetermination of 5α-androstane-3,17-dione
por: Jasinski, Jerry P., et al.
Publicado: (2010)

6-Methylideneandrost-4-ene-3,17-dione
por: Andrade, L. C. R., et al.
Publicado: (2012)

Efficient 9α-hydroxy-4-androstene-3,17-dione production by engineered Bacillus subtilis co-expressing Mycobacterium neoaurum 3-ketosteroid 9α-hydroxylase and B. subtilis glucose 1-dehydrogenase with NADH regeneration
por: Zhang, Xian, et al.
Publicado: (2016)

Complete Genome Sequence of Mycobacterium sp. Strain VKM Ac-1817D, Capable of Producing 9α-Hydroxy-androst-4-ene-3,17-dione from Phytosterol
por: Shtratnikova, Victoriya Y., et al.
Publicado: (2015)

Fungal transformation of androsta-1,4-diene-3,17-dione by Aspergillus brasiliensis
por: Hosseinabadi, Tahereh, et al.
Publicado: (2014)

Microbial Modifications of Androstane and Androstene Steroids by Penicillium vinaceum
por: Panek, Anna, et al.
Publicado: (2020)

11α,15α-Dihydroxyandrost-4-ene-3,17-dione
por: Shen, Yan-Bing, et al.
Publicado: (2011)

N-tert-Butyl-3-hydroxy-5-androstene-17-carboxamide monohydrate
por: Li, Jiang-Sheng, et al.
Publicado: (2009)

Structural Stereochemistry of Androstene Hormones Determines Interactions with Human Androgen, Estrogen, and Glucocorticoid Receptors
por: Shaak, Thomas L., et al.
Publicado: (2013)

Polyamines Disrupt the KaiABC Oscillator by Inducing Protein Denaturation
por: Li, Jinkui, et al.
Publicado: (2019)

Copper-catalyzed intramolecular cross dehydrogenative coupling approach to coumestans from 2′-hydroxyl-3-arylcoumarins
por: Song, Xianheng, et al.
Publicado: (2019)

Visible light mediated organocatalytic dehydrogenative aza-coupling of 1,3-diones using aryldiazonium salts
por: Das, Ramanand, et al.
Publicado: (2023)

Phytosterols and Cardiovascular Disease
por: Makhmudova, Umidakhon, et al.
Publicado: (2021)

Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors
por: Cheng, Xiyao, et al.
Publicado: (2022)

Phytosterol Contents of Edible Oils and Their Contributions to Estimated Phytosterol Intake in the Chinese Diet
por: Yang, Ruinan, et al.
Publicado: (2019)

Enhanced Production of Androst-1,4-Diene-3,17-Dione by Mycobacterium neoaurum JC-12 Using Three-Stage Fermentation Strategy
por: Shao, Minglong, et al.
Publicado: (2015)

Neurosteroids as Selective Inhibitors of Glycine Receptor Activity: Structure-Activity Relationship Study on Endogenous Androstanes and Androstenes
por: Bukanova, Julia V., et al.
Publicado: (2020)

Auto‐Tandem Catalysis: Pd(II)‐Catalysed Dehydrogenation/Oxidative Heck Reaction of Cyclopentane‐1,3‐diones
por: Lamb, Claire J. C., et al.
Publicado: (2017)

Discovery of 16-Androstenes (Androstenone and Androstenol), Their Synthesis Pathway, and Possible Role in Reproduction of Mouse Deer (Moschiola indica)
por: Kumar, Vinod, et al.
Publicado: (2022)

Phytosterols, Phytostanols, and Lipoprotein Metabolism
por: Gylling, Helena, et al.
Publicado: (2015)

Inhibition of Phytosterol Biosynthesis by Azasterols
por: Darnet, Sylvain, et al.
Publicado: (2020)

Missa KV 317 Krönungsmesse = Coronation mass = Messe du couronnement /
por: Mozart, Wolfgang Amadeus, 1756-1791
Publicado: (1992)

Catalytic conversion of ethane to valuable products through non-oxidative dehydrogenation and dehydroaromatization
por: Saito, Hikaru, et al.
Publicado: (2020)

11β,17aα-Dihydroxy-17aβ-methyl-d-homoandrosta-1,4-diene-3,17-dione monohydrate
por: Qiu, Ya, et al.
Publicado: (2009)

Intracellular Environment Improvement of Mycobacterium neoaurum for Enhancing Androst-1,4-Diene-3,17-Dione Production by Manipulating NADH and Reactive Oxygen Species Levels
por: Shao, Minglong, et al.
Publicado: (2019)

Phytosterol oxidation products (POP) in foods with added phytosterols and estimation of their daily intake: A literature review
por: Lin, Yuguang, et al.
Publicado: (2016)

P55PIK Regulates P53-Dependent Apoptosis in Cancer Cells by Interacting with P53 DNA-Specific Domain
por: Li, Chaoxing, et al.
Publicado: (2020)

Plasma Biomarker of Dietary Phytosterol Intake
por: Lin, Xiaobo, et al.
Publicado: (2015)

Phytosterols, Cholesterol Control, and Cardiovascular Disease
por: Poli, Andrea, et al.
Publicado: (2021)

Phytosterol Profiles, Genomes and Enzymes – An Overview
por: Darnet, Sylvain, et al.
Publicado: (2021)

Phytosterols in rice bran and their health benefits
por: Liu, Zhaoguo, et al.
Publicado: (2023)

Catalytic Mechanism of Liquid-Metal Indium for Direct Dehydrogenative Conversion of Methane to Higher Hydrocarbons
por: Nishikawa, Yuta, et al.
Publicado: (2020)

Heterologous expression and characterization of a 3-ketosteroid-∆(1)-dehydrogenase from Gordonia neofelifaecis and its utilization in the bioconversion of androst-4,9(11)-dien-3,17-dione
por: Wang, Weiyi, et al.
Publicado: (2017)

CERN Proposal SPSC/P317; the CLOUD experiment
por: Kirkby, Jasper, et al.
Publicado: (2004)

Cannot write session to /tmp/vufind_sessions/sess_cgjfrmg39rsvlbopo4nkhall8l