Genetic and Physiological Effects of Insulin on Human Urate Homeostasis

Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. To explore this association further we studied the effects of genetic variation in insulin-associated pathways on serum urate (S...

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Detalles Bibliográficos
Autores principales: Mandal, Asim K., Leask, Megan P., Estiverne, Christopher, Choi, Hyon K., Merriman, Tony R., Mount, David B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366499/
https://www.ncbi.nlm.nih.gov/pubmed/34408667
http://dx.doi.org/10.3389/fphys.2021.713710

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366499/
https://www.ncbi.nlm.nih.gov/pubmed/34408667
http://dx.doi.org/10.3389/fphys.2021.713710

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