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Genetic and Physiological Effects of Insulin on Human Urate Homeostasis

Insulin and hyperinsulinemia reduce renal fractional excretion of urate (FeU) and play a key role in the genesis of hyperuricemia and gout, via uncharacterized mechanisms. To explore this association further we studied the effects of genetic variation in insulin-associated pathways on serum urate (S...

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Detalles Bibliográficos
Autores principales:	Mandal, Asim K., Leask, Megan P., Estiverne, Christopher, Choi, Hyon K., Merriman, Tony R., Mount, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366499/ https://www.ncbi.nlm.nih.gov/pubmed/34408667 http://dx.doi.org/10.3389/fphys.2021.713710

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