LFZ-4-46, a tetrahydroisoquinoline derivative, induces apoptosis and cell cycle arrest via induction of DNA damage and activation of MAPKs pathway in cancer cells

LFZ-4-46, that is [2-hydroxy-1-phenyl-1,5,6,10b-tetrahydropyrazolo(5,1-a) isoquinolin-3(2H)-yl](phenyl) methanone, a tetrahydroisoquinoline derivative with a pyrazolidine moiety, was synthetically prepared. The anti-cancer mechanism of the compound has not been clarified yet. In this study, the anti...

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Detalles Bibliográficos
Autores principales: Xu, Lili, Huang, Guozheng, Zhu, Zhihui, Tian, Shasha, Wei, Yingying, Hong, Huanwu, Lu, Xiaowei, Li, Ying, Liu, Feize, Zhao, Huajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2021
Materias:
Preclinical Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366768/
https://www.ncbi.nlm.nih.gov/pubmed/33929988
http://dx.doi.org/10.1097/CAD.0000000000001077

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366768/
https://www.ncbi.nlm.nih.gov/pubmed/33929988
http://dx.doi.org/10.1097/CAD.0000000000001077

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