Deep geometric representations for modeling effects of mutations on protein-protein binding affinity

Modeling the impact of amino acid mutations on protein-protein interaction plays a crucial role in protein engineering and drug design. In this study, we develop GeoPPI, a novel structure-based deep-learning framework to predict the change of binding affinity upon mutations. Based on the three-dimen...

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Detalles Bibliográficos
Autores principales: Liu, Xianggen, Luo, Yunan, Li, Pengyong, Song, Sen, Peng, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366979/
https://www.ncbi.nlm.nih.gov/pubmed/34347784
http://dx.doi.org/10.1371/journal.pcbi.1009284

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366979/
https://www.ncbi.nlm.nih.gov/pubmed/34347784
http://dx.doi.org/10.1371/journal.pcbi.1009284

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