Quantitative measurement of the histological features of alpha-1 antitrypsin deficiency-associated liver disease in biopsy specimens

BACKGROUND: Pathological mutations in Alpha-1 Antitrypsin (AAT) protein cause retention of toxic polymers in the hepatocyte endoplasmic reticulum. The risk for cirrhosis in AAT deficiency is likely directly related to retention of these polymers within the liver. Polymers are classically identified...

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Detalles Bibliográficos
Autores principales: Marek, George, Collinsworth, Amy, Liu, Chen, Brantly, Mark, Clark, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366994/
https://www.ncbi.nlm.nih.gov/pubmed/34398915
http://dx.doi.org/10.1371/journal.pone.0256117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8366994/
https://www.ncbi.nlm.nih.gov/pubmed/34398915
http://dx.doi.org/10.1371/journal.pone.0256117

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