Near-physiological-temperature serial crystallography reveals conformations of SARS-CoV-2 main protease active site for improved drug repurposing

The COVID-19 pandemic has resulted in 198 million reported infections and more than 4 million deaths as of July 2021 (covid19.who.int). Research to identify effective therapies for COVID-19 includes: (1) designing a vaccine as future protection; (2) de novo drug discovery; and (3) identifying existi...

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Autores principales: Durdagi, Serdar, Dağ, Çağdaş, Dogan, Berna, Yigin, Merve, Avsar, Timucin, Buyukdag, Cengizhan, Erol, Ismail, Ertem, Fatma Betul, Calis, Seyma, Yildirim, Gunseli, Orhan, Muge D., Guven, Omur, Aksoydan, Busecan, Destan, Ebru, Sahin, Kader, Besler, Sabri O., Oktay, Lalehan, Shafiei, Alaleh, Tolu, Ilayda, Ayan, Esra, Yuksel, Busra, Peksen, Ayse B., Gocenler, Oktay, Yucel, Ali D., Can, Ozgur, Ozabrahamyan, Serena, Olkan, Alpsu, Erdemoglu, Ece, Aksit, Fulya, Tanisali, Gokhan, Yefanov, Oleksandr M., Barty, Anton, Tolstikova, Alexandra, Ketawala, Gihan K., Botha, Sabine, Dao, E. Han, Hayes, Brandon, Liang, Mengning, Seaberg, Matthew H., Hunter, Mark S., Batyuk, Alex, Mariani, Valerio, Su, Zhen, Poitevin, Frederic, Yoon, Chun Hong, Kupitz, Christopher, Sierra, Raymond G., Snell, Edward H., DeMirci, Hasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367086/
https://www.ncbi.nlm.nih.gov/pubmed/34403647
http://dx.doi.org/10.1016/j.str.2021.07.007

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367086/
https://www.ncbi.nlm.nih.gov/pubmed/34403647
http://dx.doi.org/10.1016/j.str.2021.07.007

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