Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma

BACKGROUND: Smoothened inhibitors (SMOi) have shown activity in Sonic Hedgehog (SHH) medulloblastoma, however this therapeutic class was not developed in children due to severe effects reported on growth. We hereby report long-term follow-up of young patients treated with SMOi for recurrent medullob...

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Detalles Bibliográficos
Autores principales: Pereira, Victor, Torrejon, Jacob, Kariyawasam, Dulanjalee, Berlanga, Pablo, Guerrini-Rousseau, Léa, Ayrault, Olivier, Varlet, Pascale, Tauziède-Espariat, Arnault, Puget, Stéphanie, Bolle, Stéphanie, Beccaria, Kevin, Blauwblomme, Thomas, Brugières, Laurence, Grill, Jacques, Geoerger, Birgit, Dufour, Christelle, Abbou, Samuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367281/
https://www.ncbi.nlm.nih.gov/pubmed/34409296
http://dx.doi.org/10.1093/noajnl/vdab097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367281/
https://www.ncbi.nlm.nih.gov/pubmed/34409296
http://dx.doi.org/10.1093/noajnl/vdab097

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