Cargando…

Clinical and molecular analysis of smoothened inhibitors in Sonic Hedgehog medulloblastoma

BACKGROUND: Smoothened inhibitors (SMOi) have shown activity in Sonic Hedgehog (SHH) medulloblastoma, however this therapeutic class was not developed in children due to severe effects reported on growth. We hereby report long-term follow-up of young patients treated with SMOi for recurrent medullob...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pereira, Victor, Torrejon, Jacob, Kariyawasam, Dulanjalee, Berlanga, Pablo, Guerrini-Rousseau, Léa, Ayrault, Olivier, Varlet, Pascale, Tauziède-Espariat, Arnault, Puget, Stéphanie, Bolle, Stéphanie, Beccaria, Kevin, Blauwblomme, Thomas, Brugières, Laurence, Grill, Jacques, Geoerger, Birgit, Dufour, Christelle, Abbou, Samuel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367281/ https://www.ncbi.nlm.nih.gov/pubmed/34409296 http://dx.doi.org/10.1093/noajnl/vdab097

Ejemplares similares

Role of neoadjuvant chemotherapy in metastatic medulloblastoma: a comparative study in 92 children
por: Guerrini-Rousseau, Léa, et al.
Publicado: (2020)

Prognostic Clinical and Biologic Features for Overall Survival after Relapse in Childhood Medulloblastoma
por: Huybrechts, Sophie, et al.
Publicado: (2020)

Immunohistochemistry as a tool to identify ELP1-associated medulloblastoma
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2022)

MBCL-02. ROLE OF PREOPERATIVE CHEMOTHERAPY IN METASTATIC MEDULLOBLASTOMA: A COMPARATIVE STUDY IN 92 CHILDREN
por: Guerrini-Rousseau, Léa, et al.
Publicado: (2020)

MEDB-84. The French experience of ELP1-related medulloblastomas
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2022)

Pediatric high-grade glioma MYCN is frequently associated with Li-Fraumeni syndrome
por: Guerrini-Rousseau, Léa, et al.
Publicado: (2023)

DIPG-58. HISTONE H3 WILD-TYPE DIPG/DMG OVEREXPRESSING EZHIP EXTEND THE SPECTRUM OF DIFFUSE MIDLINE GLIOMAS WITH PRC2 INHIBITION BEYOND H3-K27M MUTATION
por: Castel, David, et al.
Publicado: (2020)

A comprehensive analysis of infantile central nervous system tumors to improve distinctive criteria for infant‐type hemispheric glioma versus desmoplastic infantile ganglioglioma/astrocytoma
por: Tauziède‐Espariat, Arnault, et al.
Publicado: (2023)

DIPG-61. RESCUE REGIMENS AFTER BIOMEDE: POSSIBLE INFLUENCE ON OS ASSESSMENT
por: Carlo, Daniela Di, et al.
Publicado: (2020)

NF1-like optic pathway gliomas in children: clinical and molecular characterization of this specific presentation
por: Lobón-Iglesias, María Jesús, et al.
Publicado: (2019)

A sellar presentation of a WNT-activated embryonal tumor: further evidence of an ectopic medulloblastoma
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2023)

DIPG-38. PATIENT-DERIVED THREE-DIMENSIONAL AVATARS REVEAL CELL-AUTONOMOUS MECHANISMS DRIVING INVASION AND METASTATIC PROGRESSION IN DIFFUSE MIDLINE GLIOMAS
por: Bruschi, Marco, et al.
Publicado: (2023)

NF2 and ZFTA evaluation in the diagnostic algorithm of pediatric posterior fossa ependymoma with H3K27ME3 retained expression
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2023)

Deep intronic hotspot variant explaining rhabdoid tumor predisposition syndrome in two patients with atypical teratoid and rhabdoid tumor
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2017)

Mesenchymal non-meningothelial tumors of the central nervous system: a literature review and diagnostic update of novelties and emerging entities
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2023)

DIPG-43. CLINICAL AND MOLECULAR CHARACTERISTIC OF A NEW SUBTYPE OF DMG, H3K27-ALTERED WITH MAPK-ACTIVATING CO-DRIVER MUTATIONS
por: Auffret, Lucie, et al.
Publicado: (2023)

MBCL-21. GERMLINE ELONGATOR MUTATIONS IN SONIC HEDGEHOG MEDULLOBLASTOMA
por: Robinson, Giles W, et al.
Publicado: (2020)

Posterior fossa ependymoma H3 K27-mutant: an integrated radiological and histomolecular tumor analysis
por: Mariet, Cassandra, et al.
Publicado: (2022)

Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2021)

Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma
por: Rickert, Daniel, et al.
Publicado: (2021)

Deciphering the genetic and epigenetic landscape of pediatric bithalamic tumors
por: Tauziède‐Espariat, Arnault, et al.
Publicado: (2021)

Diagnostics of pediatric supratentorial RELA ependymomas: integration of information from histopathology, genetics, DNA methylation and imaging
por: Pagès, Mélanie, et al.
Publicado: (2018)

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
por: Rimkus, Tadas K., et al.
Publicado: (2016)

EZHIP is a specific diagnostic biomarker for posterior fossa ependymomas, group PFA and diffuse midline gliomas H3-WT with EZHIP overexpression
por: Antin, C., et al.
Publicado: (2020)

The histomolecular criteria established for adult anaplastic pilocytic astrocytoma are not applicable to the pediatric population
por: Gareton, Albane, et al.
Publicado: (2019)

Disseminated diffuse midline gliomas, H3K27-altered mimicking diffuse leptomeningeal glioneuronal tumors: a diagnostical challenge!
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2022)

An integrative radiological, histopathological and molecular analysis of pediatric pontine histone-wildtype glioma with MYCN amplification (HGG-MYCN)
por: Tauziède-Espariat, A., et al.
Publicado: (2019)

NrCAM modulates sonic hedgehog signalling by controlling smoothened translocation in the cilium
por: Basu, B, et al.
Publicado: (2015)

Expression Pattern of Sonic Hedgehog, Patched and Smoothened in Clear Cell Renal Carcinoma
por: Dunatov Huljev, Ana, et al.
Publicado: (2023)

An integrative histopathological and epigenetic characterization of primary intracranial mesenchymal tumors, FET:CREB‐fused broadening the spectrum of tumor entities in comparison with their soft tissue counterparts
por: Tauziède‐Espariat, Arnault, et al.
Publicado: (2021)

Papillary glioneuronal tumors: histological and molecular characteristics and diagnostic value of SLC44A1-PRKCA fusion
por: Pages, Melanie, et al.
Publicado: (2015)

New in vivo avatars of diffuse intrinsic pontine gliomas (DIPG) from stereotactic biopsies performed at diagnosis
por: Plessier, Alexandre, et al.
Publicado: (2017)

A malignant choroid plexus tumour with prevailing immature blastematous elements
por: Tauziède‐Espariat, Arnault, et al.
Publicado: (2021)

Nilotinib, an approved leukemia drug, inhibits smoothened signaling in Hedgehog-dependent medulloblastoma
por: Chahal, Kirti Kandhwal, et al.
Publicado: (2019)

Diagnostic accuracy of a minimal immunohistochemical panel in at/rt molecular subtyping, correlated to dna-methylation profiling
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2023)

The genomic landscape of dysembryoplastic neuroepithelial tumours and a comprehensive analysis of recurrent cases
por: Pagès, Mélanie, et al.
Publicado: (2022)

Re-irradiation of recurrent pediatric ependymoma: modalities and outcomes: a twenty-year survey
por: Lobón, Maria Jesus, et al.
Publicado: (2016)

The pediatric supratentorial MYCN-amplified high-grade gliomas methylation class presents the same radiological, histopathological and molecular features as their pontine counterparts
por: Tauziède-Espariat, A., et al.
Publicado: (2020)

HGG-40. NF1 mosaicism in a CMMRD-patient with a glioblastoma
por: Guerrini-Rousseau, Lea, et al.
Publicado: (2022)

Pediatric methylation class HGNET-MN1: unresolved issues with terminology and grading
por: Tauziède-Espariat, Arnault, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_4l6fo8sn3a3e73qrpt9r0jmb5n