Advanced oxidation protein products downregulate CYP1A2 and CYP3A4 expression and activity via the NF-κB-mediated signaling pathway in vitro and in vivo

Uremic toxin accumulation is one possible reason for alterations in hepatic drug metabolism in patients with chronic kidney disease (CKD). However, the types of uremic toxins and underlying mechanisms are poorly understood. In this study, we report the role of advanced oxidation protein products (AO...

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Detalles Bibliográficos
Autores principales: Xun, Tianrong, Lin, Zhufen, Wang, Xiaokang, Zhan, Xia, Feng, Haixing, Gan, Danna, Yang, Xixiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367815/
https://www.ncbi.nlm.nih.gov/pubmed/34031539
http://dx.doi.org/10.1038/s41374-021-00610-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367815/
https://www.ncbi.nlm.nih.gov/pubmed/34031539
http://dx.doi.org/10.1038/s41374-021-00610-9

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