A minimal physiologically based pharmacokinetic model for high-dose methotrexate

PURPOSE: High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of MTX, which is mostly excreted renally. HDMTX dosages are prescribed as a function of body surface area where...

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Detalles Bibliográficos
Autores principales: Pesenti, Giuseppe, Foppoli, Marco, Manca, Davide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367929/
https://www.ncbi.nlm.nih.gov/pubmed/34120234
http://dx.doi.org/10.1007/s00280-021-04305-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367929/
https://www.ncbi.nlm.nih.gov/pubmed/34120234
http://dx.doi.org/10.1007/s00280-021-04305-2

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