Cargando…

A minimal physiologically based pharmacokinetic model for high-dose methotrexate

PURPOSE: High-dose methotrexate (HDMTX) is administered for the treatment of a variety of malignant tumors. Wide intra- and inter-individual variabilities characterize the pharmacokinetics of MTX, which is mostly excreted renally. HDMTX dosages are prescribed as a function of body surface area where...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pesenti, Giuseppe, Foppoli, Marco, Manca, Davide
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367929/ https://www.ncbi.nlm.nih.gov/pubmed/34120234 http://dx.doi.org/10.1007/s00280-021-04305-2

Ejemplares similares

The pharmacokinetics of high-dose methotrexate in people living with HIV on antiretroviral therapy
por: Dalla Pria, Alessia, et al.
Publicado: (2015)

Physiologically-based pharmacokinetic simulations in pharmacotherapy: selection of the optimal administration route for exogenous melatonin
por: Savoca, Adriana, et al.
Publicado: (2019)

Effect of Missed Doses on the Therapeutic Effect of Methotrexate for Rheumatoid Arthritis: A Pharmacokinetic Modeling Study
por: Morrison, Alan, et al.
Publicado: (2021)

Systematic Review of Pharmacogenetic Factors That Influence High-Dose Methotrexate Pharmacokinetics in Pediatric Malignancies
por: Taylor, Zachary L., et al.
Publicado: (2021)

Population Pharmacokinetics of High-Dose Methotrexate in Chinese Pediatric Patients With Acute Lymphoblastic Leukemia
por: Gao, Xuan, et al.
Publicado: (2021)

Development of a population pharmacokinetics and pharmacodynamics model of glucarpidase rescue treatment after high-dose methotrexate therapy
por: Fukaya, Yutaka, et al.
Publicado: (2023)

Minimal physiologically‐based hybrid model of pharmacokinetics in pregnant women: Application to antenatal corticosteroids
por: Krzyzanski, Wojciech, et al.
Publicado: (2023)

Intravitreal injection of methotrexate in an experimental rabbit model: Determination of pharmacokinetics
por: Ozkan, Ebru Bener, et al.
Publicado: (2011)

Application of physiologically based pharmacokinetic modeling for sertraline dosing recommendations in pregnancy
por: George, Blessy, et al.
Publicado: (2020)

Population Pharmacokinetics of High-dose Methotrexate After Intravenous Administration in Chinese Osteosarcoma Patients from a Single Institution
por: Zhang, Wei, et al.
Publicado: (2015)

ATLAS mPBPK: A MATLAB‐Based Tool for Modeling and Simulation of Minimal Physiologically‐Based Pharmacokinetic Models
por: Mavroudis, Panteleimon D., et al.
Publicado: (2019)

Dose selection of chloroquine phosphate for treatment of COVID-19 based on a physiologically based pharmacokinetic model
por: Cui, Cheng, et al.
Publicado: (2020)

Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague
por: Nguyen, Dung, et al.
Publicado: (2021)

Physiologically based pharmacokinetic modeling for dose optimization of quinine–phenobarbital coadministration in patients with cerebral malaria
por: Sae‐heng, Teerachat, et al.
Publicado: (2021)

Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz
por: Siccardi, Marco, et al.
Publicado: (2013)

Evaluation of body-surface-area adjusted dosing of high-dose methotrexate by population pharmacokinetics in a large cohort of cancer patients
por: Arshad, Usman, et al.
Publicado: (2021)

Physiologically Based Pharmacokinetic Modelling to Identify Physiological and Drug Parameters Driving Pharmacokinetics in Obese Individuals
por: Berton, Mattia, et al.
Publicado: (2022)

Urine volume to hydration volume ratio is associated with pharmacokinetics of high‐dose methotrexate in patients with primary central nervous system lymphoma
por: Isono, Tetsuichiro, et al.
Publicado: (2021)

Clinical covariates that improve the description of high dose methotrexate pharmacokinetics in a diverse population to inform MTXPK.org
por: Taylor, Zachary L., et al.
Publicado: (2023)

Influence of pretreatment of piperazine ferulate on pharmacokinetic parameters of methotrexate in methotrexate-induced renal injury model rats by HPLC-MS
por: Shi, Huiyan, et al.
Publicado: (2017)

Propsective evaluation of high‐dose methotrexate pharmacokinetics in adult patients with lymphoma using novel determinants of kidney function
por: Barreto, Jason N., et al.
Publicado: (2021)

Application of Minimal Physiologically-Based Pharmacokinetic Model to Simulate Lung and Trachea Exposure of Pyronaridine and Artesunate in Hamsters
por: Kang, Dong Wook, et al.
Publicado: (2023)

Physiologically based pharmacokinetic modeling of nanoceria systemic distribution in rats suggests dose- and route-dependent biokinetics
por: Carlander, Ulrika, et al.
Publicado: (2018)

Physiologically-based pharmacokinetic modeling of nafamostat to support dose selection for treatment of pediatric patients with COVID-19
por: Cho, Yong-Soon, et al.
Publicado: (2022)

Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children
por: Jiang, X-L, et al.
Publicado: (2013)

External Evaluation of Population Pharmacokinetic Models of Methotrexate for Model-Informed Precision Dosing in Pediatric Patients with Acute Lymphoid Leukemia
por: Wang, Shengfeng, et al.
Publicado: (2023)

Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate
por: Yang, Shi-Long, et al.
Publicado: (2015)

Target concentration achievement for efficacy and safety of patients with osteosarcoma treated with high-dose methotrexate based on individual pharmacokinetics: A retrospective study
por: Nagamine, Ayumu, et al.
Publicado: (2022)

Physiologically based pharmacokinetic modeling of daptomycin dose optimization in pediatric patients with renal impairment
por: Ye, Lingling, et al.
Publicado: (2022)

Physiologically-based pharmacokinetic modelling and dosing evaluation of gentamicin in neonates using PhysPK
por: Zazo, Hinojal, et al.
Publicado: (2022)

Development of minimal physiologically-based pharmacokinetic-pharmacodynamic models for characterizing cellular kinetics of CAR T cells following local deliveries in mice
por: Tsai, Chia-Hung, et al.
Publicado: (2022)

Treatment success with two doses of methotrexate vs single dose of methotrexate in Ectopic Tubal Pregnancy
por: Khakwani, Mehnaz, et al.
Publicado: (2022)

Prediction of lisinopril pediatric dose from the reference adult dose by employing a physiologically based pharmacokinetic model
por: Rashid, Memoona, et al.
Publicado: (2020)

A Minimal Physiologically Based Pharmacokinetic Model to Characterize CNS Distribution of Metronidazole in Neuro Care ICU Patients
por: Chauzy, Alexia, et al.
Publicado: (2022)

Predictions of Bedaquiline and Pretomanid Target Attainment in Lung Lesions of Tuberculosis Patients using Translational Minimal Physiologically Based Pharmacokinetic Modeling
por: Mehta, Krina, et al.
Publicado: (2023)

Is folate absorption impaired by high dose methotrexate?
por: Pinkerton, C. R.
Publicado: (1983)

Preventing and Managing Toxicities of High-Dose Methotrexate
por: Howard, Scott C., et al.
Publicado: (2016)

Corrigendum to: Prospective evaluation of high‐dose methotrexate pharmacokinetics in adult patients with lymphoma using novel determinants of kidney function
Publicado: (2022)

A Comprehensive Framework for Physiologically‐Based Pharmacokinetic Modeling in Matlab
por: Stader, Felix, et al.
Publicado: (2019)

Integration of Physiologically-Based Pharmacokinetic Modeling into Early Clinical Development: An Investigation of the Pharmacokinetic Nonlinearity
por: Zhou, L, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_fh4mcicq6380kf8gb3i3rore93