How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer

Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy. The Kang team elucidated a glucocorticoid receptor-centred chemotherapy-resistance mechanism to cisplatin and charac...

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Detalles Bibliográficos
Autores principales: Clarisse, Dorien, De Bosscher, Karolien
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367998/
https://www.ncbi.nlm.nih.gov/pubmed/34400619
http://dx.doi.org/10.1038/s41467-021-24847-6
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author Clarisse, Dorien
De Bosscher, Karolien
author_facet Clarisse, Dorien
De Bosscher, Karolien
author_sort Clarisse, Dorien
collection PubMed
description Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy. The Kang team elucidated a glucocorticoid receptor-centred chemotherapy-resistance mechanism to cisplatin and characterized avenues towards a viable escape strategy.
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spelling pubmed-83679982021-09-02 How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer Clarisse, Dorien De Bosscher, Karolien Nat Commun Comment Synthetic glucocorticoids serve as co-medication against solid malignant tumors. However, glucocorticoid receptor activation may promote unsolicited cancer resistance to chemotherapy. The Kang team elucidated a glucocorticoid receptor-centred chemotherapy-resistance mechanism to cisplatin and characterized avenues towards a viable escape strategy. Nature Publishing Group UK 2021-08-16 /pmc/articles/PMC8367998/ /pubmed/34400619 http://dx.doi.org/10.1038/s41467-021-24847-6 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Comment
Clarisse, Dorien
De Bosscher, Karolien
How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_full How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_fullStr How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_full_unstemmed How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_short How the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
title_sort how the glucocorticoid receptor contributes to platinum-based therapy resistance in solid cancer
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8367998/
https://www.ncbi.nlm.nih.gov/pubmed/34400619
http://dx.doi.org/10.1038/s41467-021-24847-6
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