Crystal structure of the INTS3/INTS6 complex reveals the functional importance of INTS3 dimerization in DSB repair

SOSS1 is a single-stranded DNA (ssDNA)-binding protein complex that plays a critical role in double-strand DNA break (DSB) repair. SOSS1 consists of three subunits: INTS3, SOSSC, and hSSB1, with INTS3 serving as a scaffold to stabilize this complex. Moreover, the integrator complex subunit 6 (INTS6)...

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Detalles Bibliográficos
Autores principales: Jia, Yu, Cheng, Zixiu, Bharath, Sakshibeedu R., Sun, Qiangzu, Su, Nannan, Huang, Jun, Song, Haiwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368002/
https://www.ncbi.nlm.nih.gov/pubmed/34400606
http://dx.doi.org/10.1038/s41421-021-00283-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368002/
https://www.ncbi.nlm.nih.gov/pubmed/34400606
http://dx.doi.org/10.1038/s41421-021-00283-0

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