Theaflavin binds to a druggable pocket of TMEM16A channel and inhibits lung adenocarcinoma cell viability

As a calcium-activated chloride channel regulated by the intracellular Ca(2+) concentration and membrane potential, TMEM16A has attracted considerable attention and has been proposed as a novel anticancer drug target. We have previously reported that the pocket above the ion conductance pore could b...

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Detalles Bibliográficos
Autores principales: Shi, Sai, Ma, Biao, Sun, Fude, Qu, Chang, An, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368026/
https://www.ncbi.nlm.nih.gov/pubmed/34329684
http://dx.doi.org/10.1016/j.jbc.2021.101016

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368026/
https://www.ncbi.nlm.nih.gov/pubmed/34329684
http://dx.doi.org/10.1016/j.jbc.2021.101016

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