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Theaflavin binds to a druggable pocket of TMEM16A channel and inhibits lung adenocarcinoma cell viability
As a calcium-activated chloride channel regulated by the intracellular Ca(2+) concentration and membrane potential, TMEM16A has attracted considerable attention and has been proposed as a novel anticancer drug target. We have previously reported that the pocket above the ion conductance pore could b...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368026/ https://www.ncbi.nlm.nih.gov/pubmed/34329684 http://dx.doi.org/10.1016/j.jbc.2021.101016 |