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Development of a specific live-cell assay for native autophagic flux

Autophagy is an evolutionarily conserved pathway mediating the breakdown of cellular proteins and organelles. Emphasizing its pivotal nature, autophagy dysfunction contributes to many diseases; nevertheless, development of effective autophagy modulating drugs is hampered by fundamental deficiencies...

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Detalles Bibliográficos
Autores principales: Safren, Nathaniel, Tank, Elizabeth M., Malik, Ahmed M., Chua, Jason P., Santoro, Nicholas, Barmada, Sami J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368035/
https://www.ncbi.nlm.nih.gov/pubmed/34303705
http://dx.doi.org/10.1016/j.jbc.2021.101003