Structural basis for ALK2/BMPR2 receptor complex signaling through kinase domain oligomerization

Upon ligand binding, bone morphogenetic protein (BMP) receptors form active tetrameric complexes, comprised of two type I and two type II receptors, which then transmit signals to SMAD proteins. The link between receptor tetramerization and the mechanism of kinase activation, however, has not been e...

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Detalles Bibliográficos
Autores principales: Agnew, Christopher, Ayaz, Pelin, Kashima, Risa, Loving, Hanna S., Ghatpande, Prajakta, Kung, Jennifer E., Underbakke, Eric S., Shan, Yibing, Shaw, David E., Hata, Akiko, Jura, Natalia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368100/
https://www.ncbi.nlm.nih.gov/pubmed/34400635
http://dx.doi.org/10.1038/s41467-021-25248-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368100/
https://www.ncbi.nlm.nih.gov/pubmed/34400635
http://dx.doi.org/10.1038/s41467-021-25248-5

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