A multiscale approach for bridging the gap between potency, efficacy, and safety of small molecules directed at membrane proteins

Membrane proteins constitute a substantial fraction of the human proteome, thus representing a vast source of therapeutic drug targets. Indeed, newly devised technologies now allow targeting “undruggable” regions of membrane proteins to modulate protein function in the cell. Despite the advances in...

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Detalles Bibliográficos
Autores principales: Aguayo-Ortiz, Rodrigo, Creech, Jeffery, Jiménez-Vázquez, Eric N., Guerrero-Serna, Guadalupe, Wang, Nulang, da Rocha, Andre Monteiro, Herron, Todd J., Espinoza-Fonseca, L. Michel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368179/
https://www.ncbi.nlm.nih.gov/pubmed/34400719
http://dx.doi.org/10.1038/s41598-021-96217-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368179/
https://www.ncbi.nlm.nih.gov/pubmed/34400719
http://dx.doi.org/10.1038/s41598-021-96217-7

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