Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging

PURPOSE: Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are reflected in O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography ([18F] FE...

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Autores principales: Liesche-Starnecker, Friederike, Prokop, Georg, Yakushev, Igor, Preibisch, Christine, Delbridge, Claire, Meyer, Hanno S., Aftahy, Kaywan, Barz, Melanie, Meyer, Bernhard, Zimmer, Claus, Schlegel, Jürgen, Wiestler, Benedikt, Gempt, Jens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368421/
https://www.ncbi.nlm.nih.gov/pubmed/34398358
http://dx.doi.org/10.1186/s13550-021-00817-3
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author Liesche-Starnecker, Friederike
Prokop, Georg
Yakushev, Igor
Preibisch, Christine
Delbridge, Claire
Meyer, Hanno S.
Aftahy, Kaywan
Barz, Melanie
Meyer, Bernhard
Zimmer, Claus
Schlegel, Jürgen
Wiestler, Benedikt
Gempt, Jens
author_facet Liesche-Starnecker, Friederike
Prokop, Georg
Yakushev, Igor
Preibisch, Christine
Delbridge, Claire
Meyer, Hanno S.
Aftahy, Kaywan
Barz, Melanie
Meyer, Bernhard
Zimmer, Claus
Schlegel, Jürgen
Wiestler, Benedikt
Gempt, Jens
author_sort Liesche-Starnecker, Friederike
collection PubMed
description PURPOSE: Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are reflected in O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography ([18F] FET PET) and magnetic resonance imaging (MRI) parameters, including cerebral blood volume (CBV), fractional anisotropy (FA) and mean diffusivity (MD). METHODS: In this prospective cohort, 162 targeted biopsies of 43 patients with therapy-naïve, isocitrate dehydrogenase (IDH) wildtype GBM were obtained after defining areas of interest based on imaging parameters [18F] FET PET, CBV, FA and MD. Histopathological analysis of cellularity and neovascularization was conducted and results correlated to imaging data. RESULTS: ANOVA analysis showed a significant increase of CBV in areas with high neovascularization. For diffusion metrics, and in particular FA, a trend for inverse association with neovascularization was found. [18F] FET PET showed a significant positive correlation to cellularity, while CBV also showed a trend towards correlation with cellularity, not reaching significant levels. In contrast, MD and FA were negatively associated with cellularity. CONCLUSION: Our study confirms that amino acid PET and MR imaging parameters are indicative of histological tumor properties in glioblastoma and highlights the ability of multimodal imaging to assess tumor biology non-invasively.
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spelling pubmed-83684212021-08-31 Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging Liesche-Starnecker, Friederike Prokop, Georg Yakushev, Igor Preibisch, Christine Delbridge, Claire Meyer, Hanno S. Aftahy, Kaywan Barz, Melanie Meyer, Bernhard Zimmer, Claus Schlegel, Jürgen Wiestler, Benedikt Gempt, Jens EJNMMI Res Original Research PURPOSE: Combining imaging modalities has become an essential tool for assessment of tumor biology in glioblastoma (GBM) patients. Aim of this study is to understand how tumor cellularity and neovascularization are reflected in O-(2-[18F]fluoroethyl)-L-tyrosine positron emission tomography ([18F] FET PET) and magnetic resonance imaging (MRI) parameters, including cerebral blood volume (CBV), fractional anisotropy (FA) and mean diffusivity (MD). METHODS: In this prospective cohort, 162 targeted biopsies of 43 patients with therapy-naïve, isocitrate dehydrogenase (IDH) wildtype GBM were obtained after defining areas of interest based on imaging parameters [18F] FET PET, CBV, FA and MD. Histopathological analysis of cellularity and neovascularization was conducted and results correlated to imaging data. RESULTS: ANOVA analysis showed a significant increase of CBV in areas with high neovascularization. For diffusion metrics, and in particular FA, a trend for inverse association with neovascularization was found. [18F] FET PET showed a significant positive correlation to cellularity, while CBV also showed a trend towards correlation with cellularity, not reaching significant levels. In contrast, MD and FA were negatively associated with cellularity. CONCLUSION: Our study confirms that amino acid PET and MR imaging parameters are indicative of histological tumor properties in glioblastoma and highlights the ability of multimodal imaging to assess tumor biology non-invasively. Springer Berlin Heidelberg 2021-08-16 /pmc/articles/PMC8368421/ /pubmed/34398358 http://dx.doi.org/10.1186/s13550-021-00817-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Research
Liesche-Starnecker, Friederike
Prokop, Georg
Yakushev, Igor
Preibisch, Christine
Delbridge, Claire
Meyer, Hanno S.
Aftahy, Kaywan
Barz, Melanie
Meyer, Bernhard
Zimmer, Claus
Schlegel, Jürgen
Wiestler, Benedikt
Gempt, Jens
Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging
title Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging
title_full Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging
title_fullStr Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging
title_full_unstemmed Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging
title_short Visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion MRI and FET-PET imaging
title_sort visualizing cellularity and angiogenesis in newly-diagnosed glioblastoma with diffusion and perfusion mri and fet-pet imaging
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368421/
https://www.ncbi.nlm.nih.gov/pubmed/34398358
http://dx.doi.org/10.1186/s13550-021-00817-3
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