Cargando…

Protective effect of LNA-anti-miR-132 therapy on liver fibrosis in mice

microRNAs (miRs) are small regulatory RNAs that are frequently deregulated in liver disease. Liver fibrosis is characterized by excessive scarring caused by chronic inflammatory processes. In this study, we determined the functional role of miR-132 using a locked nucleic acid (LNA)-anti-miR approach...

Descripción completa

Detalles Bibliográficos
Autores principales:	Momen-Heravi, Fatemeh, Catalano, Donna, Talis, Austin, Szabo, Gyongyi, Bala, Shashi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8368790/ https://www.ncbi.nlm.nih.gov/pubmed/34458001 http://dx.doi.org/10.1016/j.omtn.2021.05.007

Ejemplares similares

Exosomes derived from alcohol-treated hepatocytes horizontally transfer liver specific miRNA-122 and sensitize monocytes to LPS
por: Momen-Heravi, Fatemeh, et al.
Publicado: (2015)

Exosomes from Hepatitis C Infected Patients Transmit HCV Infection and Contain Replication Competent Viral RNA in Complex with Ago2-miR122-HSP90
por: Bukong, Terence N., et al.
Publicado: (2014)

Biodistribution and function of extracellular miRNA-155 in mice
por: Bala, Shashi, et al.
Publicado: (2015)

Therapeutic inhibition of miR-155 attenuates liver fibrosis via STAT3 signaling
por: Bala, Shashi, et al.
Publicado: (2023)

Alcohol Promotes Exosome Biogenesis and Release via Modulating Rabs and miR-192 Expression in Human Hepatocytes
por: Bala, Shashi, et al.
Publicado: (2022)

Increased number of circulating exosomes and their microRNA cargos are potential novel biomarkers in alcoholic hepatitis
por: Momen-Heravi, Fatemeh, et al.
Publicado: (2015)

Extracellular vesicles in oral squamous carcinoma carry oncogenic miRNA profile and reprogram monocytes via NF-κB pathway
por: Momen-Heravi, Fatemeh, et al.
Publicado: (2018)

Deficiency of miR‐208a Exacerbates CCl(4)‐Induced Acute Liver Injury in Mice by Activating Cell Death Pathways
por: Bala, Shashi, et al.
Publicado: (2020)

MicroRNA-155 Deficiency Attenuates Liver Steatosis and Fibrosis without Reducing Inflammation in a Mouse Model of Steatohepatitis
por: Csak, Timea, et al.
Publicado: (2015)

MicroRNA Signature in Alcoholic Liver Disease
por: Bala, Shashi, et al.
Publicado: (2012)

Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes
por: Pang, Maoyin, et al.
Publicado: (2011)

Acute Binge Drinking Increases Serum Endotoxin and Bacterial DNA Levels in Healthy Individuals
por: Bala, Shashi, et al.
Publicado: (2014)

Increased microRNA-155 expression in the serum and peripheral monocytes in chronic HCV infection
por: Bala, Shashi, et al.
Publicado: (2012)

Down-regulation of the tumor suppressor miR-34a contributes to head and neck cancer by up-regulating the MET oncogene and modulating tumor immune evasion
por: Wu, Xun, et al.
Publicado: (2021)

LNA-anti-miR-150 ameliorated kidney injury of lupus nephritis by inhibiting renal fibrosis and macrophage infiltration
por: Luan, Junjun, et al.
Publicado: (2019)

LNA-anti-miR-150 alleviates renal interstitial fibrosis by reducing pro-inflammatory M1/M2 macrophage polarization
por: Hao, Xiangnan, et al.
Publicado: (2022)

Advances in Roles of miR-132 in the Nervous System
por: Qian, Yun, et al.
Publicado: (2017)

A role for miR-132 in learned safety
por: Ronovsky, Marianne, et al.
Publicado: (2019)

miR-155 Down Regulation by LNA Inhibitor can Reduce Cell Growth and Proliferation in PC12 Cell Line
por: Kouhkan, Fatemeh, et al.
Publicado: (2011)

Melatonin Protects Cholangiocytes from Oxidative Stress-Induced Proapoptotic and Proinflammatory Stimuli via miR-132 and miR-34
por: Ostrycharz, Ewa, et al.
Publicado: (2020)

Mechanisms Underlying Dysregulation of miR-132 in Alzheimer’s Disease
por: Song, Qiaoyun, et al.
Publicado: (2019)

Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates
por: Gallo Cantafio, Maria Eugenia, et al.
Publicado: (2016)

Pharmacokinetics and Pharmacodynamics of a 13-mer LNA-inhibitor-miR-221 in Mice and Non-human Primates
Publicado: (2016)

Changes in miR-124-1, miR-212, miR-132, miR-134, and miR-155 Expression Patterns after 7,12-Dimethylbenz(a)anthracene Treatment in CBA/Ca Mice
por: Tomesz, Andras, et al.
Publicado: (2022)

Acute meningitis in rats is associated with decreased levels of miR132 and miR146a
por: Jagoo, Mubareka, et al.
Publicado: (2014)

SIRT1, miR-132 and miR-212 link human longevity to Alzheimer’s Disease
por: Hadar, A., et al.
Publicado: (2018)

miR-212 and miR-132 Are Downregulated in Neurally Derived Plasma Exosomes of Alzheimer’s Patients
por: Cha, Diana J., et al.
Publicado: (2019)

Targeting LDL Cholesterol With LNA
por: Krieg, Arthur M
Publicado: (2012)

In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
por: Torres, Anna, et al.
Publicado: (2016)

Mir-1, miR-122, miR-132, and miR-133 Are Related to Subclinical Aortic Atherosclerosis Associated with Metabolic Syndrome
por: Šatrauskienė, Agnė, et al.
Publicado: (2021)

The expression and clinical significance of miR-132 in gastric cancer patients
por: Liu, Xiaowen, et al.
Publicado: (2014)

Diagnostic value and significance of serum miR-132 combined with miR-223 for sepsis-induced cardiomyopathy
por: Li, Yanping, et al.
Publicado: (2021)

Relationship between circulating miR-132 and non-alcoholic fatty liver disease in a Chinese population
por: Zong, Yicen, et al.
Publicado: (2020)

Different Effects on Protein Expression of CDR132L, an Antisense Inhibitor of miR-132, and Standard Therapies for Myocardial Infarction
por: Iborra-Egea, Oriol, et al.
Publicado: (2022)

Erratum to: In vitro and in vivo activity of miR-92a–Locked Nucleic Acid (LNA)–Inhibitor against endometrial cancer
por: Torres, Anna, et al.
Publicado: (2016)

In vivo effects of olive oil and trans-fatty acids on miR-134, miR-132, miR-124-1, miR-9-3 and mTORC1 gene expression in a DMBA-treated mouse model
por: Molnar, Richard, et al.
Publicado: (2021)

Experience-dependent expression of miR132 regulates ocular dominance plasticity
por: Tognini, Paola, et al.
Publicado: (2011)

miR-212/132 expression and functions: within and beyond the neuronal compartment
por: Wanet, Anaïs, et al.
Publicado: (2012)

miR-132 Mediates the Integration of Newborn Neurons into the Adult Dentate Gyrus
por: Luikart, Bryan W., et al.
Publicado: (2011)

Control of Angiogenesis via a VHL/miR-212/132 Axis
por: Lei, Zhiyong, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_2k6h4ppicmetfkrtoh3e939t3o