Ligand-Based and Docking-Based Virtual Screening of MDM2 Inhibitors as Potent Anticancer Agents

A ligand-based and docking-based virtual screening was carried out to identify novel MDM2 inhibitors. A pharmacophore model with four features was used for virtual screening, followed by molecular docking. Seventeen compounds were selected for an in vitro MDM2 inhibition assay, and compounds AO-476/...

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Detalles Bibliográficos
Autores principales: Li, Bing-Hui, Ge, Jun-Qi, Wang, Ya-Li, Wang, Li-Jun, Zhang, Qi, Bian, Cong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369186/
https://www.ncbi.nlm.nih.gov/pubmed/34413896
http://dx.doi.org/10.1155/2021/3195957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369186/
https://www.ncbi.nlm.nih.gov/pubmed/34413896
http://dx.doi.org/10.1155/2021/3195957

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