PGC1α is required for the renoprotective effect of lncRNA Tug1 in vivo and links Tug1 with urea cycle metabolites

lncRNA taurine-upregulated gene 1 (Tug1) is a promising therapeutic target in the progression of diabetic nephropathy (DN), but the molecular basis of its protection remains poorly understood. Here, we generate a triple-mutant diabetic mouse model coupled with metabolomic profiling data to interroga...

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Detalles Bibliográficos
Autores principales: Li, Li, Long, Jianyin, Mise, Koki, Galvan, Daniel L., Overbeek, Paul A., Tan, Lin, Kumar, Shwetha V., Chan, Wai Kin, Lorenzi, Phillip L., Chang, Benny H., Danesh, Farhad R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369494/
https://www.ncbi.nlm.nih.gov/pubmed/34380028
http://dx.doi.org/10.1016/j.celrep.2021.109510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369494/
https://www.ncbi.nlm.nih.gov/pubmed/34380028
http://dx.doi.org/10.1016/j.celrep.2021.109510

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