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Immunotherapeutic Blockade of CD47 Inhibitory Signaling Enhances Innate and Adaptive Immune Responses to Viral Infection

Paradoxically, early host responses to infection include the upregulation of the antiphagocytic molecule, CD47. This suggests that CD47 blockade could enhance antigen presentation and subsequent immune responses. Indeed, mice treated with anti-CD47 monoclonal antibody following lymphocytic choriomen...

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Detalles Bibliográficos
Autores principales: Cham, Lamin B., Torrez Dulgeroff, Laughing Bear, Tal, Michal Caspi, Adomati, Tom, Li, Fanghui, Bhat, Hilal, Huang, Anfei, Lang, Philipp A., Moreno, Mary E., Rivera, Jose M., Galkina, Sofiya A., Kosikova, Galina, Stoddart, Cheryl A., McCune, Joseph M., Myers, Lara M., Weissman, Irving L., Lang, Karl S., Hasenkrug, Kim J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369894/
https://www.ncbi.nlm.nih.gov/pubmed/32294445
http://dx.doi.org/10.1016/j.celrep.2020.03.058