Deuterium‐Stabilized (R)‐Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity

The antidiabetic drug pioglitazone is, to date, the most efficacious oral drug recommended off‐label for the treatment of nondiabetic or diabetic patients with biopsy‐proven nonalcoholic steatohepatitis (NASH). However, weight gain and edema side effects have limited its use for NASH. Pioglitazone i...

Descripción completa

Detalles Bibliográficos
Autores principales: Jacques, Vincent, Bolze, Sébastien, Hallakou‐Bozec, Sophie, Czarnik, Anthony W., Divakaruni, Ajit S., Fouqueray, Pascale, Murphy, Anne N., Van der Ploeg, Lex H.T., DeWitt, Sheila
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369945/
https://www.ncbi.nlm.nih.gov/pubmed/34430785
http://dx.doi.org/10.1002/hep4.1723

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8369945/
https://www.ncbi.nlm.nih.gov/pubmed/34430785
http://dx.doi.org/10.1002/hep4.1723

Ejemplares similares