Blocking Bacterial Naphthohydroquinone Oxidation and ADP-Ribosylation Improves Activity of Rifamycins against Mycobacterium abscessus

Rifampicin is an effective drug for treating tuberculosis (TB) but is not used to treat Mycobacterium abscessus infections due to poor in vitro activity. While rifabutin, another rifamycin, has better anti-M. abscessus activity, its activity is far from the nanomolar potencies of rifamycins against...

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Detalles Bibliográficos
Autores principales: Ganapathy, Uday S., Lan, Tian, Krastel, Philipp, Lindman, Marissa, Zimmerman, Matthew D., Ho, HsinPin, Sarathy, Jansy P., Evans, Joanna C., Dartois, Véronique, Aldrich, Courtney C., Dick, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370238/
https://www.ncbi.nlm.nih.gov/pubmed/34228543
http://dx.doi.org/10.1128/AAC.00978-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370238/
https://www.ncbi.nlm.nih.gov/pubmed/34228543
http://dx.doi.org/10.1128/AAC.00978-21

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