Key Metabolic Enzymes Involved in Remdesivir Activation in Human Lung Cells

Remdesivir (RDV; GS-5734, Veklury), the first FDA-approved antiviral to treat COVID-19, is a single-diastereomer monophosphoramidate prodrug of an adenosine analogue. RDV is taken up in the target cells and metabolized in multiple steps to form the active nucleoside triphosphate (TP) (GS-443902), wh...

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Detalles Bibliográficos
Autores principales: Li, Ruidong, Liclican, Albert, Xu, Yili, Pitts, Jared, Niu, Congrong, Zhang, Jingyu, Kim, Cynthia, Zhao, Xiaofeng, Soohoo, Daniel, Babusis, Darius, Yue, Qin, Ma, Bin, Murray, Bernard P., Subramanian, Raju, Xie, Xuping, Zou, Jing, Bilello, John P., Li, Li, Schultz, Brian E., Sakowicz, Roman, Smith, Bill J., Shi, Pei-Yong, Murakami, Eisuke, Feng, Joy Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2021
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370248/
https://www.ncbi.nlm.nih.gov/pubmed/34125594
http://dx.doi.org/10.1128/AAC.00602-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370248/
https://www.ncbi.nlm.nih.gov/pubmed/34125594
http://dx.doi.org/10.1128/AAC.00602-21

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