Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis

We recently described aberrantly increased cytoplasmic SFPQ intron-retaining transcripts (IRTs) and concurrent SFPQ protein mislocalization as new hallmarks of amyotrophic lateral sclerosis (ALS). However, the generalizability and potential roles of cytoplasmic IRTs in health and disease remain uncl...

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Detalles Bibliográficos
Autores principales: Tyzack, Giulia E, Neeves, Jacob, Crerar, Hamish, Klein, Pierre, Ziff, Oliver, Taha, Doaa M, Luisier, Raphaëlle, Luscombe, Nicholas M, Patani, Rickie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370440/
https://www.ncbi.nlm.nih.gov/pubmed/33693641
http://dx.doi.org/10.1093/brain/awab078

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370440/
https://www.ncbi.nlm.nih.gov/pubmed/33693641
http://dx.doi.org/10.1093/brain/awab078

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