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Aberrant cytoplasmic intron retention is a blueprint for RNA binding protein mislocalization in VCP-related amyotrophic lateral sclerosis
We recently described aberrantly increased cytoplasmic SFPQ intron-retaining transcripts (IRTs) and concurrent SFPQ protein mislocalization as new hallmarks of amyotrophic lateral sclerosis (ALS). However, the generalizability and potential roles of cytoplasmic IRTs in health and disease remain uncl...
Autores principales: | Tyzack, Giulia E, Neeves, Jacob, Crerar, Hamish, Klein, Pierre, Ziff, Oliver, Taha, Doaa M, Luisier, Raphaëlle, Luscombe, Nicholas M, Patani, Rickie |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370440/ https://www.ncbi.nlm.nih.gov/pubmed/33693641 http://dx.doi.org/10.1093/brain/awab078 |
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