The kinetics of islet amyloid polypeptide phase-separated system and hydrogel formation are critically influenced by macromolecular crowding

Many protein misfolding diseases (e.g. type II diabetes and Alzheimer's disease) are characterised by amyloid deposition. Human islet amyloid polypeptide (hIAPP, involved in type II diabetes) spontaneously undergoes liquid–liquid phase separation (LLPS) and a kinetically complex hydrogelation,...

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Detalles Bibliográficos
Autores principales: Pytowski, Lior, Vaux, David J., Jean, Létitia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2021
Materias:
Molecular Bases of Health & Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370757/
https://www.ncbi.nlm.nih.gov/pubmed/34313292
http://dx.doi.org/10.1042/BCJ20210384

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370757/
https://www.ncbi.nlm.nih.gov/pubmed/34313292
http://dx.doi.org/10.1042/BCJ20210384

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