Insulin-producing β-cells regenerate ectopically from a mesodermal origin under the perturbation of hemato-endothelial specification

To investigate the role of the vasculature in pancreatic β-cell regeneration, we crossed a zebrafish β-cell ablation model into the avascular npas4l mutant (i.e. cloche). Surprisingly, β-cell regeneration increased markedly in npas4l mutants owing to the ectopic differentiation of β-cells in the mes...

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Detalles Bibliográficos
Autores principales: Liu, Ka-Cheuk, Villasenor, Alethia, Bertuzzi, Maria, Schmitner, Nicole, Radros, Niki, Rautio, Linn, Mattonet, Kenny, Matsuoka, Ryota L, Reischauer, Sven, Stainier, Didier YR, Andersson, Olov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2021
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370765/
https://www.ncbi.nlm.nih.gov/pubmed/34403334
http://dx.doi.org/10.7554/eLife.65758

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8370765/
https://www.ncbi.nlm.nih.gov/pubmed/34403334
http://dx.doi.org/10.7554/eLife.65758

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