SFPQ rescues F508del-CFTR expression and function in cystic fibrosis bronchial epithelial cells

Cystic fibrosis (CF) occurs as a result of mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which lead to misfolding, trafficking defects, and impaired function of the CFTR protein. Splicing factor proline/glutamine-rich (SFPQ) is a multifunctional nuclear RNA-bindin...

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Detalles Bibliográficos
Autores principales: Kumar, Parameet, Soni, Dharmendra Kumar, Sen, Chaitali, Larsen, Mads B., Mazan-Mamczarz, Krystyna, Piao, Yulan, De, Supriyo, Gorospe, Myriam, Frizzell, Raymond A., Biswas, Roopa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371023/
https://www.ncbi.nlm.nih.gov/pubmed/34404863
http://dx.doi.org/10.1038/s41598-021-96141-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371023/
https://www.ncbi.nlm.nih.gov/pubmed/34404863
http://dx.doi.org/10.1038/s41598-021-96141-w

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