ELMO1 signaling is a promoter of osteoclast function and bone loss

Osteoporosis affects millions worldwide and is often caused by osteoclast induced bone loss. Here, we identify the cytoplasmic protein ELMO1 as an important ‘signaling node’ in osteoclasts. We note that ELMO1 SNPs associate with bone abnormalities in humans, and that ELMO1 deletion in mice reduces b...

Descripción completa

Detalles Bibliográficos
Autores principales: Arandjelovic, Sanja, Perry, Justin S. A., Zhou, Ming, Ceroi, Adam, Smirnov, Igor, Walk, Scott F., Shankman, Laura S., Cambré, Isabelle, Onengut-Gumuscu, Suna, Elewaut, Dirk, Conrads, Thomas P., Ravichandran, Kodi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371122/
https://www.ncbi.nlm.nih.gov/pubmed/34404802
http://dx.doi.org/10.1038/s41467-021-25239-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371122/
https://www.ncbi.nlm.nih.gov/pubmed/34404802
http://dx.doi.org/10.1038/s41467-021-25239-6

Ejemplares similares