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Examination of CA1 Hippocampal DNA Methylation as a Mechanism for Closing of Estrogen’s Critical Window

There is a critical window for estrogen replacement therapy, beyond which estradiol (E2) fails to enhance cognition and N-methyl-D-aspartate (NMDA) receptor function, and E2-responsive transcription decreases. Much less attention has been given to the mechanism for closing of the critical window, wh...

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Detalles Bibliográficos
Autores principales: Sinha, Puja, Rani, Asha, Kumar, Ashok, Riva, Alberto, Brant, Jason Orr, Foster, Thomas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371553/
https://www.ncbi.nlm.nih.gov/pubmed/34421577
http://dx.doi.org/10.3389/fnagi.2021.717032