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Zelen design clinical trials: why, when, and how

BACKGROUND: In 1979, Marvin Zelen proposed a new design for randomized clinical trials intended to facilitate clinicians’ and patients’ participation. The defining innovation of Zelen’s proposal was random assignment of treatment prior to patient or participant consent. Following randomization, a pa...

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Detalles Bibliográficos
Autores principales: Simon, Gregory E., Shortreed, Susan M., DeBar, Lynn L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8371763/
https://www.ncbi.nlm.nih.gov/pubmed/34404466
http://dx.doi.org/10.1186/s13063-021-05517-w