Truncated S-MGBs: towards a parasite-specific and low aggregation chemotype

This paper describes the design and synthesis of Strathclyde minor groove binders (S-MGBs) that have been truncated by the removal of a pyrrole ring in order to mimic the structure of the natural product, disgocidine. S-MGBs have been found to be active against many different organisms, however, sel...

Descripción completa

Detalles Bibliográficos
Autores principales: Brooke, Daniel P., McGee, Leah M. C., Giordani, Federica, Cross, Jasmine M., Khalaf, Abedawn I., Irving, Craig, Gillingwater, Kirsten, Shaw, Craig D., Carter, Katharine C., Barrett, Michael P., Suckling, Colin J., Scott, Fraser J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372214/
https://www.ncbi.nlm.nih.gov/pubmed/34447938
http://dx.doi.org/10.1039/d1md00110h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372214/
https://www.ncbi.nlm.nih.gov/pubmed/34447938
http://dx.doi.org/10.1039/d1md00110h

Ejemplares similares