Discovering protein–protein interaction stabilisers by native mass spectrometry

Protein–protein interactions (PPIs) are key therapeutic targets. Most PPI-targeting drugs in the clinic inhibit these important interactions; however, stabilising PPIs is an attractive alternative in cases where a PPI is disrupted in a disease state. The discovery of novel PPI stabilisers has been h...

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Detalles Bibliográficos
Autores principales: Bellamy-Carter, Jeddidiah, Mohata, Manjari, Falcicchio, Marta, Basran, Jaswir, Higuchi, Yusuke, Doveston, Richard G., Leney, Aneika C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2021
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372317/
https://www.ncbi.nlm.nih.gov/pubmed/34447561
http://dx.doi.org/10.1039/d1sc01450a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372317/
https://www.ncbi.nlm.nih.gov/pubmed/34447561
http://dx.doi.org/10.1039/d1sc01450a

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