Structural and Genomic Insights Into Pyrazinamide Resistance in Mycobacterium tuberculosis Underlie Differences Between Ancient and Modern Lineages

Resistance to drugs used to treat tuberculosis disease (TB) continues to remain a public health burden, with missense point mutations in the underlying Mycobacterium tuberculosis bacteria described for nearly all anti-TB drugs. The post-genomics era along with advances in computational and structura...

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Detalles Bibliográficos
Autores principales: Tunstall, Tanushree, Phelan, Jody, Eccleston, Charlotte, Clark, Taane G., Furnham, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Molecular Biosciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372558/
https://www.ncbi.nlm.nih.gov/pubmed/34422898
http://dx.doi.org/10.3389/fmolb.2021.619403

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8372558/
https://www.ncbi.nlm.nih.gov/pubmed/34422898
http://dx.doi.org/10.3389/fmolb.2021.619403

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